Formate Metabolism

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Formate Metabolism by Animal Tissues*?

Many studies on the metabolism of formic acid by a variety of animal tissues have shown that an appreciable portion of this substrate is oxidized to carbon dioxide (6-13). Since the initial observation of Battelli (6) and Battelli and Stern (7) on the oxidation in vitro of formate, various uncorrelated attempts have been made to identify the responsible enzymes to explain the mechanism of this ...

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Formate metabolism in fetal and neonatal sheep.

By virtue of its role in nucleotide synthesis, as well as the provision of methyl groups for vital methylation reactions, one-carbon metabolism plays a crucial role in growth and development. Formate, a critical albeit neglected component of one-carbon metabolism, occurs extracellularly and may provide insights into cellular events. We examined formate metabolism in chronically cannulated fetal...

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The relationship of folic acid to formate metabolism in the rat; formate incorporation into purines.

The considerations which prompted an investigation of the r61e of folic acid in formate metabolism were discussed in an earlier paper (1) in which it was reported that rats deficient in this vitamin incorporated less of a standard dose of CY4-formate into certain amino acids and heme than did rats fed folic acid. There is abundant microbiological evidence to indicate an interrelationship betwee...

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Kinetics of Formate Metabolism in Methanobacterium formicicum and Methanospirillum hungatei.

The kinetics of formate metabolism in Methanobacterium formicicum and Methanospirillum hungatei were studied with log-phase formate-grown cultures. The progress of formate degradation was followed by the formyltetrahydrofolate synthetase assay for formate and fitted to the integrated form of the Michaelis-Menten equation. The K(m) and V(max) values for Methanobacterium formicicum were 0.58 mM f...

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Oxalate, formate, formamide, and methanol metabolism in Thiobacillus novellus.

Thiobacillus novellus was able to grow with oxalate, formate, formamide, and methanol as sole sources of carbon and energy. Extensive growth on methanol required yeast extract or vitamins. Glyoxylate carboligase was detected in extracts of oxalate-grown cells. Ribulose bisphosphate carboxylase was found in extracts of cells grown on formate, formamide, and thiosulfate. These data indicate that ...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1963

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)67878-0